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KIR Panel

Happilyeverafter
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1 Posts
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Posted on: 22-Mar-2015 1:35pm
Dear Dr. Braverman,I read on your site that certain KIR proteins combined with certain HLA genes can predispose a child to genetic risk for autism. In your immune panel, you order HLA panels for both parents, but a KIR panel only for the mother. For purposes of assessing risk for autism, would it be helpful for the father to have a KIR panel done as well?
Dr Braverman
Member
4 Posts
-1.  Posted on: 27-Mar-2015 4:38pm
RE: KIR Panel

The cross talk between KIR and HLA proteins potentially leading to autism when altered, occurs between a mother and her fetus. Indeed, KIR proteins are localized on the surface of uterine NK cells (immune cells localized in the uterus).

So there is no need to have a KIR panel done for the father as he is in no way involved in the maternal immune tolerance towards the fetus
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